TY - JOUR T1 - Familial gastric cancer: overview and guidelines for management* JF - Journal of Medical Genetics JO - J Med Genet SP - 873 LP - 880 DO - 10.1136/jmg.36.12.873 VL - 36 IS - 12 AU - Carlos Caldas AU - Fatima Carneiro AU - Henry T Lynch AU - Jun Yokota AU - Georgia L Wiesner AU - Steven M Powell AU - Frank R Lewis AU - David G Huntsman AU - Paul D P Pharoah AU - Janusz A Jankowski AU - Patrick MacLeod AU - Holger Vogelsang AU - Gisela Keller AU - Ken G M Park AU - Frances M Richards AU - Eamonn R Maher AU - Simon A Gayther AU - Carla Oliveira AU - Nicola Grehan AU - Derek Wight AU - Raquel Seruca AU - Franco Roviello AU - Bruce A J Ponder AU - Charles E Jackson Y1 - 1999/12/01 UR - http://jmg.bmj.com/content/36/12/873.abstract N2 - Families with autosomal dominant inherited predisposition to gastric cancer have been described. More recently, germlineE-cadherin/CDH1mutations have been identified in hereditary diffuse gastric cancer kindred. The need to have protocols to manage and counsel these families in the clinic led a group of geneticists, gastroenterologists, surgeons, oncologists, pathologists, and molecular biologists to convene a workshop to produce consensus statements and guidelines for familial gastric cancer. Review of the available cancer pathology from people belonging to families with documented germlineE-cadherin/CDH1mutations confirmed that the gastric cancers were all of the diffuse type. Criteria to define the different types of familial gastric cancer syndromes were agreed. Foremost among these criteria was that review of histopathology should be part of the evaluation of any family with aggregation of gastric cancer cases. Guidelines for genetic testing and counselling in hereditary diffuse gastric cancer were produced. Finally, a proposed strategy for clinical management in families with high penetrance autosomal dominant predisposition to gastric cancer was defined. ER -