RT Journal Article SR Electronic T1 Familial gastric cancer: overview and guidelines for management* JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 873 OP 880 DO 10.1136/jmg.36.12.873 VO 36 IS 12 A1 Carlos Caldas A1 Fatima Carneiro A1 Henry T Lynch A1 Jun Yokota A1 Georgia L Wiesner A1 Steven M Powell A1 Frank R Lewis A1 David G Huntsman A1 Paul D P Pharoah A1 Janusz A Jankowski A1 Patrick MacLeod A1 Holger Vogelsang A1 Gisela Keller A1 Ken G M Park A1 Frances M Richards A1 Eamonn R Maher A1 Simon A Gayther A1 Carla Oliveira A1 Nicola Grehan A1 Derek Wight A1 Raquel Seruca A1 Franco Roviello A1 Bruce A J Ponder A1 Charles E Jackson YR 1999 UL http://jmg.bmj.com/content/36/12/873.abstract AB Families with autosomal dominant inherited predisposition to gastric cancer have been described. More recently, germlineE-cadherin/CDH1mutations have been identified in hereditary diffuse gastric cancer kindred. The need to have protocols to manage and counsel these families in the clinic led a group of geneticists, gastroenterologists, surgeons, oncologists, pathologists, and molecular biologists to convene a workshop to produce consensus statements and guidelines for familial gastric cancer. Review of the available cancer pathology from people belonging to families with documented germlineE-cadherin/CDH1mutations confirmed that the gastric cancers were all of the diffuse type. Criteria to define the different types of familial gastric cancer syndromes were agreed. Foremost among these criteria was that review of histopathology should be part of the evaluation of any family with aggregation of gastric cancer cases. Guidelines for genetic testing and counselling in hereditary diffuse gastric cancer were produced. Finally, a proposed strategy for clinical management in families with high penetrance autosomal dominant predisposition to gastric cancer was defined.