RT Journal Article SR Electronic T1 Club foot, an adverse outcome of early amniocentesis: disruption or deformation? JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 843 OP 846 DO 10.1136/jmg.36.11.843 VO 36 IS 11 A1 S A Farrell A1 A M Summers A1 L Dallaire A1 J Singer A1 Jo-Ann M Johnson A1 R D Wilson YR 1999 UL http://jmg.bmj.com/content/36/11/843.abstract AB An association between the occurrence of club foot and early amniocentesis has been reported. The largest of these randomised studies was the Canadian Early and Mid-Trimester Amniocentesis Trial. Data describing the neonatal outcome, focusing on this association, are presented. Possible mechanisms for the association and the implications for the development of club foot are discussed.