RT Journal Article SR Electronic T1 The ACE gene and Alzheimer's disease susceptibility JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 695 OP 697 DO 10.1136/jmg.37.9.695 VO 37 IS 9 A1 Yolanda Narain A1 Agustin Yip A1 Terence Murphy A1 Carol Brayne A1 Douglas Easton A1 John Grimley Evans A1 John Xuereb A1 Nigel Cairns A1 Margaret M Esiri A1 Robert A Furlong A1 David C Rubinsztein YR 2000 UL http://jmg.bmj.com/content/37/9/695.abstract AB A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged >73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While the APOEε4 allele was strongly associated with AD risk in our series, we found no evidence for an interaction between the APOE andACE loci. In addition, no interactions were observed between ACE and gender or age at death of the AD cases. A meta-analysis of all published reports (12 case-control series in total) suggested that both the II and IDACE genotypes are associated with increased AD risk (odds ratio (OR) for II v DD 1.36, 95% confidence interval (CI)=1.13-1.63, OR for DIv DD 1.33, 95% CI=1.14-1.53, p=0.0002).