TY - JOUR T1 - The <em>ACE</em> gene and Alzheimer's disease susceptibility JF - Journal of Medical Genetics JO - J Med Genet SP - 695 LP - 697 DO - 10.1136/jmg.37.9.695 VL - 37 IS - 9 AU - Yolanda Narain AU - Agustin Yip AU - Terence Murphy AU - Carol Brayne AU - Douglas Easton AU - John Grimley Evans AU - John Xuereb AU - Nigel Cairns AU - Margaret M Esiri AU - Robert A Furlong AU - David C Rubinsztein Y1 - 2000/09/01 UR - http://jmg.bmj.com/content/37/9/695.abstract N2 - A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged &gt;73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While the APOEε4 allele was strongly associated with AD risk in our series, we found no evidence for an interaction between the APOE andACE loci. In addition, no interactions were observed between ACE and gender or age at death of the AD cases. A meta-analysis of all published reports (12 case-control series in total) suggested that both the II and IDACE genotypes are associated with increased AD risk (odds ratio (OR) for II v DD 1.36, 95% confidence interval (CI)=1.13-1.63, OR for DIv DD 1.33, 95% CI=1.14-1.53, p=0.0002). ER -