PT - JOURNAL ARTICLE AU - Narain, Yolanda AU - Yip, Agustin AU - Murphy, Terence AU - Brayne, Carol AU - Easton, Douglas AU - Evans, John Grimley AU - Xuereb, John AU - Cairns, Nigel AU - Esiri, Margaret M AU - Furlong, Robert A AU - Rubinsztein, David C TI - The <em>ACE</em> gene and Alzheimer's disease susceptibility AID - 10.1136/jmg.37.9.695 DP - 2000 Sep 01 TA - Journal of Medical Genetics PG - 695--697 VI - 37 IP - 9 4099 - http://jmg.bmj.com/content/37/9/695.short 4100 - http://jmg.bmj.com/content/37/9/695.full SO - J Med Genet2000 Sep 01; 37 AB - A recent study suggested that the insertion (I) allele in intron 16 of the angiotensin converting enzyme gene (ACE) is associated with Alzheimer's disease (AD) risk. In our series of 239 necropsy confirmed late onset AD cases and 342 elderly non-demented controls aged &gt;73 years, we found significantly different ACE genotype distributions in the case and control groups (p=0.007). Homozygotes for both the I and D alleles were associated with a higher risk compared to DI heterozygotes. While the APOEε4 allele was strongly associated with AD risk in our series, we found no evidence for an interaction between the APOE andACE loci. In addition, no interactions were observed between ACE and gender or age at death of the AD cases. A meta-analysis of all published reports (12 case-control series in total) suggested that both the II and IDACE genotypes are associated with increased AD risk (odds ratio (OR) for II v DD 1.36, 95% confidence interval (CI)=1.13-1.63, OR for DIv DD 1.33, 95% CI=1.14-1.53, p=0.0002).