RT Journal Article
SR Electronic
T1 Genetics of club foot in Maori and Pacific people
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 680
OP 683
DO 10.1136/jmg.37.9.680
VO 37
IS 9
A1 Cyril Chapman
A1 N Susan Stott
A1 Ramari Viola Port
A1 Richard O Nicol
YR 2000
UL http://jmg.bmj.com/content/37/9/680.abstract
AB The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the computer program POINTER. This analysis shows that the best genetic model for club foot in this population is a single dominant gene with a penetrance of 33% and a predicted gene frequency of 0.9%. These data provide a scientific foundation for molecular studies in the Maori and Polynesian population to identify putative club foot genes.