PT  - JOURNAL ARTICLE
AU  - Cyril Chapman
AU  - N Susan Stott
AU  - Ramari Viola Port
AU  - Richard O Nicol
TI  - Genetics of club foot in Maori and Pacific people
AID  - 10.1136/jmg.37.9.680
DP  - 2000 Sep 01
TA  - Journal of Medical Genetics
PG  - 680--683
VI  - 37
IP  - 9
4099  - http://jmg.bmj.com/content/37/9/680.short
4100  - http://jmg.bmj.com/content/37/9/680.full
SO  - J Med Genet2000 Sep 01; 37
AB  - The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the computer program POINTER. This analysis shows that the best genetic model for club foot in this population is a single dominant gene with a penetrance of 33% and a predicted gene frequency of 0.9%. These data provide a scientific foundation for molecular studies in the Maori and Polynesian population to identify putative club foot genes.