PT  - JOURNAL ARTICLE
AU  - C Dacou-Voutetakis
AU  - A Sertedaki
AU  - M Maniatis-Christidis
AU  - C Sarri
AU  - G Karadima
AU  - M B Petersen
AU  - A Xaidara
AU  - M Kanariou
AU  - P Nicolaidou
TI  - Insulin dependent diabetes mellitus (IDDM) and autoimmune thyroiditis in a boy with a ring chromosome 18: additional evidence of autoimmunity or IDDM gene(s) on chromosome 18
AID  - 10.1136/jmg.36.2.156
DP  - 1999 Feb 01
TA  - Journal of Medical Genetics
PG  - 156--158
VI  - 36
IP  - 2
4099  - http://jmg.bmj.com/content/36/2/156.short
4100  - http://jmg.bmj.com/content/36/2/156.full
SO  - J Med Genet1999 Feb 01; 36
AB  - A 4 year 3 month old boy with insulin dependent diabetes mellitus (IDDM), autoimmune thyroiditis, slight mental retardation, facial dysmorphism, and a de novo ring chromosome 18 (deletion 18q22.3-18qter) is described. This unique association of defects could represent a chance association. Alternatively, the clinical features could be the result of the chromosomal aberration. If so, one could speculate that a gene or genes on chromosome 18 might act as a suppressor or activator of the autoimmune process by itself or in concert with other IDDM loci.