RT Journal Article
SR Electronic
T1 A model protocol evaluating the introduction of genetic assessment for women with a family history of breast cancer
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 192
OP 196
DO 10.1136/jmg.37.3.192
VO 37
IS 3
A1 Gray, Jonathon
A1 Brain, Kate
A1 Norman, Paul
A1 Anglim, Cathy
A1 France, Liz
A1 Barton, Garry
A1 Branston, Lucy
A1 Parsons, Evelyn
A1 Clarke, Angus
A1 Sampson, Julian
A1 Roberts, Elizabeth
A1 Newcombe, Robert
A1 Cohen, David
A1 Rogers, Cerilan
A1 Mansel, Robert
A1 Harper, Peter
YR 2000
UL http://jmg.bmj.com/content/37/3/192.abstract
AB Randomised controlled trials allow comparisons to be made between different models of service delivery, but have not been used in the field of clinical genetics. With the advent of clinical governance, the evidence provided by such trials will be increasingly important in informing and shaping clinical genetics practice. The TRACE project (Trial of genetic assessment in breast cancer) is a randomised controlled trial of genetic assessment for women who are at increased risk of breast cancer because of their family history. The absence of cancer genetics service provision in Wales before this study gave a window of opportunity in which this important trial could be conducted. The present paper describes how TRACE will provide crucial evidence regarding the psychosocial as well as resource implications of adding individualised genetic assessment, genetic counselling, and (where appropriate) gene testing to typical advice and surveillance from a hospital breast clinic. In addition, it is anticipated that TRACE will represent a model for future trials of service delivery in the increasing number of complex genetic disorders where evidence on the economic implications of screening and management is currently limited.