RT Journal Article
SR Electronic
T1 Genetic association of an<em>LBP-1c</em>/<em>CP2</em>/<em>LSF</em>gene polymorphism with late onset Alzheimer's disease
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 232
OP 233
DO 10.1136/jmg.38.4.232
VO 38
IS 4
A1 Taylor, Alison E
A1 Yip, Agustin
A1 Brayne, Carol
A1 Easton, Douglas
A1 Evans, John Grimley
A1 Xuereb, John
A1 Cairns, Nigel
A1 Esiri, Margaret M
A1 Rubinsztein, David C
YR 2001
UL http://jmg.bmj.com/content/38/4/232.abstract
AB OBJECTIVES The only locus unequivocally associated with late onset Alzheimer's disease (AD) risk is APOE. However, this locus accounts for less than half the genetic variance. A recent study suggested that the A allele of the 3′UTR biallelic polymorphism in theLBP-1c/CP2/LSFgene was associated with reduced AD risk. Samples were diagnosed predominantly by clinical rather than pathological criteria. We have sought to replicate this finding in a series of necropsy confirmed, late onset AD cases and non-demented controls. METHODS The 3′UTR polymorphism in theLBP-1c/CP2/LSFgene was typed in 216 necropsy confirmed AD cases and 301 non-demented controls aged &gt;73 years. RESULTS We found differentLBP-1c/CP2/LSFallele distributions in our AD cases and controls (p=0.048); the A allele was associated with reduced AD risk. The allele and genotype frequencies observed in our cases and controls were similar to those previously reported. No significant effects emerged when the data were adjusted for age, sex, or apoE ε4 carrier status. CONCLUSIONS Our data supportLBP-1c/CP2/LSFas a candidate gene/risk factor for AD and provide justification for future studies to investigate the role of this gene in Alzheimer's disease.