PT - JOURNAL ARTICLE AU - H Y Handoko AU - P J Wirapati AU - H A Sudoyo AU - M Sitepu AU - S Marzuki TI - Meiotic breakpoint mapping of a proposed X linked visual loss susceptibility locus in Leber's hereditary optic neuropathy. AID - 10.1136/jmg.35.8.668 DP - 1998 Aug 01 TA - Journal of Medical Genetics PG - 668--671 VI - 35 IP - 8 4099 - http://jmg.bmj.com/content/35/8/668.short 4100 - http://jmg.bmj.com/content/35/8/668.full SO - J Med Genet1998 Aug 01; 35 AB - Leber's hereditary optic neuropathy (LHON) is a maternally inherited degenerative disorder characterised by an acute or subacute optic nerve degeneration resulting in visual failure. Mitochondrial DNA mutations have been reported and a nuclear modifier gene(s) on the X chromosome is thought to play an important role in the onset of this disorder. We analysed a LHON family with a novel and more accurate approach using 27 X chromosomal microsatellite markers. Meiotic breakpoint mapping and two point lod score did not point to any particular area on the X chromosome which might contain the X susceptibility locus.