PT  - JOURNAL ARTICLE
AU  - Ogilvie, C M
AU  - Raymond, F L
AU  - Harrison, R H
AU  - Scriven, P N
AU  - Docherty, Z
TI  - A new approach to the elucidation of complex chromosome rearrangements illustrated by a case of Rieger syndrome.
AID  - 10.1136/jmg.35.3.234
DP  - 1998 Mar 01
TA  - Journal of Medical Genetics
PG  - 234--237
VI  - 35
IP  - 3
4099  - http://jmg.bmj.com/content/35/3/234.short
4100  - http://jmg.bmj.com/content/35/3/234.full
SO  - J Med Genet1998 Mar 01; 35
AB  - A patient with a complex chromosome rearrangement and unilateral Rieger syndrome is presented. This rearrangement involves four chromosomes and six breakpoints, one of which is at 4q25, the candidate region for Rieger syndrome. We discuss a novel approach to the elucidation of this case using a multiprobe fluorescence in situ hybridisation method to show rearrangements unpredictable from G banded analysis, and the clear and unambiguous presentation of the karyotype using computer generated colour ideograms.