RT Journal Article SR Electronic T1 Rapid antibody test for prenatal diagnosis of fragile X syndrome on amniotic fluid cells: a new appraisal. JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 250 OP 251 DO 10.1136/jmg.34.3.250 VO 34 IS 3 A1 Willemsen, R A1 Los, F A1 Mohkamsing, S A1 van den Ouweland, A A1 Deelen, W A1 Galjaard, H A1 Oostra, B YR 1997 UL http://jmg.bmj.com/content/34/3/250.abstract AB Fragile X syndrome is caused by mutations in the FMR1 gene and is one of the most frequent forms of inherited mental retardation in males. Postnatal and prenatal diagnosis of fragile X syndrome is feasible by direct DNA analysis. A new approach to prenatal diagnosis of fragile X syndrome in amniotic fluid cells is described, using a rapid and simple antibody test on uncultured amniotic fluid cells. The test requires 1 ml of amniotic fluid and the results of this antibody test are available on the same day as the amniocentesis.