RT Journal Article SR Electronic T1 Intelligence indices in people with a high/low risk for developing Huntington's disease. JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 564 OP 568 DO 10.1136/jmg.34.7.564 VO 34 IS 7 A1 de Boo, G M A1 Tibben, A A1 Lanser, J B A1 Jennekens-Schinkel, A A1 Hermans, J A1 Vegter-van der Vlis, M A1 Roos, R A YR 1997 UL http://jmg.bmj.com/content/34/7/564.abstract AB Intelligence in 20 presymptomatic subjects with an increased risk (> 95%) for carrying the gene for Huntington's disease (HD) was studied in a prospective, case-control, single blind study. No significant differences between the groups were detected for intelligence indices and subtest scores (Wechsler Adult Intelligence Scale). The high level of the performance IQ and the significant discrepancy between performance IQ and verbal IQ found in both the high risk and the low risk groups contrasted with our expectations based on anamnestic information, general clinical opinion, and the results of previously conducted studies. We propose that psychosocial circumstances could explain the test results and discuss the consequences of our findings for clinical genetics practice.