TY - JOUR T1 - Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus. JF - Journal of Medical Genetics JO - J Med Genet SP - 253 LP - 255 DO - 10.1136/jmg.33.3.253 VL - 33 IS - 3 AU - A W Thomas AU - A Edwards AU - E J Sherratt AU - A Majid AU - J Gagg AU - J C Alcolado Y1 - 1996/03/01 UR - http://jmg.bmj.com/content/33/3/253.abstract N2 - Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation. ER -