PT - JOURNAL ARTICLE AU - A W Thomas AU - A Edwards AU - E J Sherratt AU - A Majid AU - J Gagg AU - J C Alcolado TI - Molecular scanning of candidate mitochondrial tRNA genes in type 2 (non-insulin dependent) diabetes mellitus. AID - 10.1136/jmg.33.3.253 DP - 1996 Mar 01 TA - Journal of Medical Genetics PG - 253--255 VI - 33 IP - 3 4099 - http://jmg.bmj.com/content/33/3/253.short 4100 - http://jmg.bmj.com/content/33/3/253.full SO - J Med Genet1996 Mar 01; 33 AB - Mitochondrial DNA (mtDNA) gene defects may play a role in the development of non-insulin dependent diabetes mellitus (NIDDM). In order to search for potentially diabetogenic mtDNA defects we have applied the technique of single stranded conformational polymorphism (SSCP) analysis to 124 patients with a history of NIDDM and 40 non-diabetic controls. No new heteroplasmic mutations were detected. However, a variety of homoplasmic variants were found in patients with NIDDM; some of these merit further investigation.