TY - JOUR T1 - Localisation of a new gene for non-specific mental retardation to Xq22-q26 (MRX35). JF - Journal of Medical Genetics JO - J Med Genet SP - 52 LP - 55 DO - 10.1136/jmg.33.1.52 VL - 33 IS - 1 AU - X X Gu AU - R Decorte AU - P Marynen AU - J P Fryns AU - J J Cassiman AU - P Raeymaekers Y1 - 1996/01/01 UR - http://jmg.bmj.com/content/33/1/52.abstract N2 - Non-specific mental retardation (MR) is a condition in which MR appears to be the only consistent manifestation. The X linked form (MRX) is genetically heterogeneous. We report clinical, cytogenetic, and linkage data on a family with X linked non-specific MR. Two point and multi-point linkage analysis with 18 polymorphic markers, covering the entire chromosome, showed close linkage to DXS1001 and DXS425 with a maximal lod score of 2.41 at 0% recombination. DXS178 and the gene for hypoxanthine phosphoribosyl-transferase (HPRT), located in Xq22 and Xq26 respectively, flank the mutation. All other chromosomal regions could be excluded with odds of at least 100:1. To our knowledge there is currently no other non-specific MR gene mapped to this region. Therefore, the gene causing MR in this family can be considered to be a new, independent MRX locus (MRX35). ER -