@article {Gu52, author = {X X Gu and R Decorte and P Marynen and J P Fryns and J J Cassiman and P Raeymaekers}, title = {Localisation of a new gene for non-specific mental retardation to Xq22-q26 (MRX35).}, volume = {33}, number = {1}, pages = {52--55}, year = {1996}, doi = {10.1136/jmg.33.1.52}, publisher = {BMJ Publishing Group Ltd}, abstract = {Non-specific mental retardation (MR) is a condition in which MR appears to be the only consistent manifestation. The X linked form (MRX) is genetically heterogeneous. We report clinical, cytogenetic, and linkage data on a family with X linked non-specific MR. Two point and multi-point linkage analysis with 18 polymorphic markers, covering the entire chromosome, showed close linkage to DXS1001 and DXS425 with a maximal lod score of 2.41 at 0\% recombination. DXS178 and the gene for hypoxanthine phosphoribosyl-transferase (HPRT), located in Xq22 and Xq26 respectively, flank the mutation. All other chromosomal regions could be excluded with odds of at least 100:1. To our knowledge there is currently no other non-specific MR gene mapped to this region. Therefore, the gene causing MR in this family can be considered to be a new, independent MRX locus (MRX35).}, issn = {0022-2593}, URL = {https://jmg.bmj.com/content/33/1/52}, eprint = {https://jmg.bmj.com/content/33/1/52.full.pdf}, journal = {Journal of Medical Genetics} }