TY - JOUR T1 - Sequence analysis of the CCG polymorphic region adjacent to the CAG triplet repeat of the HD gene in normal and HD chromosomes. JF - Journal of Medical Genetics JO - J Med Genet SP - 399 LP - 400 DO - 10.1136/jmg.32.5.399 VL - 32 IS - 5 AU - C Pêcheux AU - J F Mouret AU - A Dürr AU - Y Agid AU - J Feingold AU - A Brice AU - C Dodé AU - J C Kaplan Y1 - 1995/05/01 UR - http://jmg.bmj.com/content/32/5/399.abstract N2 - The CAG expansion responsible for Huntington's disease (HD) is followed by an adjacent polymorphic CCG repeat region which may interfere with a PCR based diagnosis. We have sequenced this region in 52 unrelated HD patients, from both normal and HD chromosomes. Fifty percent of the normal alleles were (CCG)7(CCT)2, 48% (CCG)10(CCT)2, and 2% (CCG)7(CCT)3. In contrast (CCG)7(CCT)2 was found in 85% of the HD alleles which represents significant linkage disequilibrium with the HD mutation. ER -