TY - JOUR T1 - Mapping of the X linked form of hyper IgM syndrome (HIGM1) JF - Journal of Medical Genetics JO - J Med Genet SP - 202 LP - 205 DO - 10.1136/jmg.30.3.202 VL - 30 IS - 3 AU - M Padayachee AU - R J Levinsky AU - C Kinnon AU - A Finn AU - C McKeown AU - C Feighery AU - L D Notarangelo AU - R W Hendriks AU - A P Read AU - S Malcolm Y1 - 1993/03/01 UR - http://jmg.bmj.com/content/30/3/202.abstract N2 - X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes. ER -