RT Journal Article
SR Electronic
T1 Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 858
OP 860
DO 10.1136/jmg.29.12.858
VO 29
IS 12
A1 Crocq, M A
A1 Mant, R
A1 Asherson, P
A1 Williams, J
A1 Hode, Y
A1 Mayerova, A
A1 Collier, D
A1 Lannfelt, L
A1 Sokoloff, P
A1 Schwartz, J C
YR 1992
UL http://jmg.bmj.com/content/29/12/858.abstract
AB Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).