TY - JOUR T1 - Association between schizophrenia and homozygosity at the dopamine D3 receptor gene. JF - Journal of Medical Genetics JO - J Med Genet SP - 858 LP - 860 DO - 10.1136/jmg.29.12.858 VL - 29 IS - 12 AU - M A Crocq AU - R Mant AU - P Asherson AU - J Williams AU - Y Hode AU - A Mayerova AU - D Collier AU - L Lannfelt AU - P Sokoloff AU - J C Schwartz Y1 - 1992/12/01 UR - http://jmg.bmj.com/content/29/12/858.abstract N2 - Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26). ER -