PT  - JOURNAL ARTICLE
AU  - Crocq, M A
AU  - Mant, R
AU  - Asherson, P
AU  - Williams, J
AU  - Hode, Y
AU  - Mayerova, A
AU  - Collier, D
AU  - Lannfelt, L
AU  - Sokoloff, P
AU  - Schwartz, J C
TI  - Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
AID  - 10.1136/jmg.29.12.858
DP  - 1992 Dec 01
TA  - Journal of Medical Genetics
PG  - 858--860
VI  - 29
IP  - 12
4099  - http://jmg.bmj.com/content/29/12/858.short
4100  - http://jmg.bmj.com/content/29/12/858.full
SO  - J Med Genet1992 Dec 01; 29
AB  - Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).