RT Journal Article
SR Electronic
T1 An epidemiological study of isolated split hand/foot in Hungary, 1975-1984.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 593
OP 596
DO 10.1136/jmg.30.7.593
VO 30
IS 7
A1 A E Czeizel
A1 M Vitéz
A1 I Kodaj
A1 W Lenz
YR 1993
UL http://jmg.bmj.com/content/30/7/593.abstract
AB A population based and validated 10 year cohort of 94 cases with split hand/foot born in Hungary, 1975-1984 was evaluated. This type of congenital limb deficiency was relatively frequently (43%) associated with non-limb defects. Fifty-four cases with isolated split hand/foot are evaluated in this paper. A single limb was affected in 78% of cases. The upper limbs were 21 times more frequently affected in unimelic cases with a right sided predominance and male excess. Case-control analysis indicated intrauterine growth retardation and lower socioeconomic status of parents of cases. Family study showed six familial cases with autosomal dominant inheritance among 152 first and 452 second degree relatives. All familial cases were males.