TY - JOUR T1 - A complex chromosome rearrangement with 10 breakpoints: tentative assignment of the locus for Williams syndrome to 4q33----q35.1. JF - Journal of Medical Genetics JO - J Med Genet SP - 253 LP - 255 DO - 10.1136/jmg.29.4.253 VL - 29 IS - 4 AU - R Tupler AU - P Maraschio AU - A Gerardo AU - R Mainieri AU - G Lanzi AU - L Tiepolo Y1 - 1992/04/01 UR - http://jmg.bmj.com/content/29/4/253.abstract N2 - An unbalanced complex chromosome rearrangement with 10 breakpoints resulting in four derivative chromosomes (1, 2, 4, and 11) was found in a girl with severe phenotypic abnormalities, many of which are characteristic of Williams syndrome. The patient was monosomic for the region 4q33----q35.1 and thus the mapping of the syndrome could tentatively be restricted to this region. ER -