%0 Journal Article %A R Tupler %A P Maraschio %A A Gerardo %A R Mainieri %A G Lanzi %A L Tiepolo %T A complex chromosome rearrangement with 10 breakpoints: tentative assignment of the locus for Williams syndrome to 4q33----q35.1. %D 1992 %R 10.1136/jmg.29.4.253 %J Journal of Medical Genetics %P 253-255 %V 29 %N 4 %X An unbalanced complex chromosome rearrangement with 10 breakpoints resulting in four derivative chromosomes (1, 2, 4, and 11) was found in a girl with severe phenotypic abnormalities, many of which are characteristic of Williams syndrome. The patient was monosomic for the region 4q33----q35.1 and thus the mapping of the syndrome could tentatively be restricted to this region. %U https://jmg.bmj.com/content/jmedgenet/29/4/253.full.pdf