RT Journal Article
SR Electronic
T1 Age at onset and life table risks in genetic counselling for Huntington's disease.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 239
OP 242
DO 10.1136/jmg.29.4.239
VO 29
IS 4
A1 P S Harper
A1 R G Newcombe
YR 1992
UL http://jmg.bmj.com/content/29/4/239.abstract
AB Age related genetic risk data for carrying the gene for Huntington's disease in relatives at risk, based on a previously documented life table approach, are presented in a form allowing ready access for use in genetic counselling. Figures are given for first degree relatives and for second degree relatives showing varying age combinations of consultand and intervening parent at risk. Data are also given for the risk of developing Huntington's disease over varying finite periods in relation to age. The availability of this information in tabular form should help those involved in genetic counselling for this disorder in providing accurate risk estimates to relatives; the data are also of importance for combination with genotype information in predictive testing.