RT Journal Article
SR Electronic
T1 Neural tube defect recurrence after 'partial' vitamin supplementation.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 326
OP 329
DO 10.1136/jmg.26.5.326
VO 26
IS 5
A1 S Sheppard
A1 N C Nevin
A1 M J Seller
A1 J Wild
A1 R W Smithells
A1 A P Read
A1 R Harris
A1 D W Fielding
A1 C J Schorah
YR 1989
UL http://jmg.bmj.com/content/26/5/326.abstract
AB A total of 227 mothers enrolled for periconceptional multivitamin supplementation because of previous neural tube defect (NTD) births took vitamins for less than the recommended minimum period (at least 28 days before conception until two menstrual periods have been missed). Of 213 examined infants/fetuses born to these partially supplemented mothers, two had NTD, one of whom followed four previous NTDs. The observed NTD recurrence rate is similar to that observed in fully supplemented mothers. A further 14 mothers started supplements before the second missed period but after the normal time of neural tube closure. Three of their offspring had NTD. The significance of this apparently high recurrence rate is discussed.