RT Journal Article
SR Electronic
T1 X linked neonatal centronuclear/myotubular myopathy: evidence for linkage to Xq28 DNA marker loci.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 284
OP 287
DO 10.1136/jmg.27.5.284
VO 27
IS 5
A1 Thomas, N S
A1 Williams, H
A1 Cole, G
A1 Roberts, K
A1 Clarke, A
A1 Liechti-Gallati, S
A1 Braga, S
A1 Gerber, A
A1 Meier, C
A1 Moser, H
YR 1990
UL http://jmg.bmj.com/content/27/5/284.abstract
AB We have studied the inheritance of several polymorphic Xq27/28 DNA marker loci in two three generation families with the X linked neonatal lethal form of centronuclear/myotubular myopathy (XL MTM). We found complete linkage of XLMTM to all four informative Xq28 markers analysed, with GCP/RCP (Z = 3.876, theta = 0.00), with DXS15 (Z = 3.737, theta = 0.00), with DXS52 (Z = 2.709, theta = 0.00), and with F8C (Z = 1.020, theta = 0.00). In the absence of any observable recombination, we are unable to sublocalise the XLMTM locus further within the Xq28 region. This evidence for an Xq28 localisation may allow us to carry out useful genetic counselling within such families.