PT - JOURNAL ARTICLE AU - Thomas, N S AU - Williams, H AU - Cole, G AU - Roberts, K AU - Clarke, A AU - Liechti-Gallati, S AU - Braga, S AU - Gerber, A AU - Meier, C AU - Moser, H TI - X linked neonatal centronuclear/myotubular myopathy: evidence for linkage to Xq28 DNA marker loci. AID - 10.1136/jmg.27.5.284 DP - 1990 May 01 TA - Journal of Medical Genetics PG - 284--287 VI - 27 IP - 5 4099 - http://jmg.bmj.com/content/27/5/284.short 4100 - http://jmg.bmj.com/content/27/5/284.full SO - J Med Genet1990 May 01; 27 AB - We have studied the inheritance of several polymorphic Xq27/28 DNA marker loci in two three generation families with the X linked neonatal lethal form of centronuclear/myotubular myopathy (XL MTM). We found complete linkage of XLMTM to all four informative Xq28 markers analysed, with GCP/RCP (Z = 3.876, theta = 0.00), with DXS15 (Z = 3.737, theta = 0.00), with DXS52 (Z = 2.709, theta = 0.00), and with F8C (Z = 1.020, theta = 0.00). In the absence of any observable recombination, we are unable to sublocalise the XLMTM locus further within the Xq28 region. This evidence for an Xq28 localisation may allow us to carry out useful genetic counselling within such families.