%0 Journal Article %A J Starr %A M Lamont %A L Iselius %A J Harvey %A J Heckmatt %T A linkage study of a large pedigree with X linked centronuclear myopathy. %D 1990 %R 10.1136/jmg.27.5.281 %J Journal of Medical Genetics %P 281-283 %V 27 %N 5 %X Centronuclear myopathy (CNM) is a muscle wasting disorder that occurs in three distinct forms. Previous studies have shown linkage between the X linked form of the disease and the Xq28 probes ST14, DX13, and F8C. Our study on a previously unreported, three generation, X linked CNM family confirms linkage between these markers and the CNM locus (Z = 3.21, theta = 00). However, results from the laboratory of J-L Mandel (Samson and Hanover, personal communication) on a number of X linked CNM families exclude genetic linkage from the region Xq26-qter, suggesting genetic heterogeneity in this condition. %U https://jmg.bmj.com/content/jmedgenet/27/5/281.full.pdf