PT  - JOURNAL ARTICLE
AU  - S A McMillan
AU  - A J Hill
AU  - C A Graham
AU  - N C Nevin
AU  - A C Fay
TI  - T cell receptor beta chain polymorphisms are associated with cystic fibrosis.
AID  - 10.1136/jmg.26.7.431
DP  - 1989 Jul 01
TA  - Journal of Medical Genetics
PG  - 431--433
VI  - 26
IP  - 7
4099  - http://jmg.bmj.com/content/26/7/431.short
4100  - http://jmg.bmj.com/content/26/7/431.full
SO  - J Med Genet1989 Jul 01; 26
AB  - The BglII polymorphism near the constant region of the T cell receptor beta chain (TCR c beta) has been investigated in normal controls, patients with cystic fibrosis (CF), and CF carriers. A significant increase was found in the frequency of the 10.0:9.2 kb heterozygous genotype in the CF carrier group (71%) as compared with normal controls (44%) (p = 0.005). Patients with CF also showed an increased frequency of the heterozygous genotype but this was not significant. These results represent a previously unreported disease association and suggest that there may be some form of epistatic interaction between the CF gene and the TCR beta genes such that the double heterozygote is immunologically advantaged.