RT Journal Article SR Electronic T1 In vitro gene amplification for prenatal diagnosis of congenital adrenal hyperplasia. JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 676 OP 678 DO 10.1136/jmg.27.11.676 VO 27 IS 11 A1 Rumsby, G A1 Honour, J W YR 1990 UL http://jmg.bmj.com/content/27/11/676.abstract AB A simple, rapid, non-radioactive method for detecting homozygous deletions/conversions of the steroid 21-hydroxylase gene is described. In our experience this method will be useful for first trimester prenatal diagnosis of congenital adrenal hyperplasia in 17% of families of a child with the salt losing form. This test includes an internal control to monitor the success of amplification.