PT - JOURNAL ARTICLE AU - Fisher, J A AU - Burn, J AU - Alexander, F W AU - Gardner-Medwin, D TI - Angelman (happy puppet) syndrome in a girl and her brother. AID - 10.1136/jmg.24.5.294 DP - 1987 May 01 TA - Journal of Medical Genetics PG - 294--298 VI - 24 IP - 5 4099 - http://jmg.bmj.com/content/24/5/294.short 4100 - http://jmg.bmj.com/content/24/5/294.full SO - J Med Genet1987 May 01; 24 AB - We report a girl aged 11 and her brother aged five, both with the typical features of Angelman syndrome, and three isolated cases. This report, together with a review of published reports and contact with previous authors, has revealed a total of 41 sibs of probands, although only nine of these are known to have been later born. The possible effect of voluntary restriction of family size after the birth of an affected child is discussed in relation to the possibility of autosomal recessive inheritance, but a recurrence risk of 5% is appropriate for use in the genetic clinic.