RT Journal Article
SR Electronic
T1 Linkage analysis of a DNA polymorphism proximal to the Duchenne and Becker muscular dystrophy loci on the short arm of the X chromosome.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 179
OP 181
DO 10.1136/jmg.22.3.179
VO 22
IS 3
A1 C S Brown
A1 P L Pearson
A1 N S Thomas
A1 M Sarfarazi
A1 P S Harper
A1 D J Shaw
YR 1985
UL http://jmg.bmj.com/content/22/3/179.abstract
AB The inheritance of a restriction fragment length polymorphism (RFLP) detected by a cloned DNA sequence (p754) from the short arm of the X chromosome has been studied in 14 Duchenne muscular dystrophy kindreds and six Becker muscular dystrophy kindreds. The linkage data obtained suggest that both the DMD and BMD loci are located in the same region (p21) on the short arm of the X chromosome at a distance of about 15 to 20 cM from the 754 locus. Data from families informative for both the p754 and L1.28 polymorphisms suggest that p754 is closer to the disease loci than is L1.28.