RT Journal Article SR Electronic T1 Localisation of human alpha globin to 16p13.3----pter. JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 847 OP 849 DO 10.1136/jmg.25.12.847 VO 25 IS 12 A1 V J Buckle A1 D R Higgs A1 A O Wilkie A1 M Super A1 D J Weatherall YR 1988 UL http://jmg.bmj.com/content/25/12/847.abstract AB A female child with alpha thalassaemia trait, moderate mental retardation, and dysmorphic features has inherited an abnormal chromosome 16 complement as a result of the unbalanced segregation of a maternal balanced translocation. Cytogenetic analysis indicates that the patient is monosomic for 16p13.3----pter and trisomic for 10q26.13----qter. DNA studies show that the patient has not inherited either maternal alpha globin allele. This accounts for the alpha thalassaemia trait in the child and places the human alpha globin complex in band 16p13.3----pter.