RT Journal Article
SR Electronic
T1 Disorders of haemoglobin in China.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 578
OP 583
DO 10.1136/jmg.24.10.578
VO 24
IS 10
A1 Zeng, Y T
A1 Huang, S Z
YR 1987
UL http://jmg.bmj.com/content/24/10/578.abstract
AB A large scale survey of haemoglobinopathies and thalassaemia has been carried out in China, involving 900,000 people in 28 provinces. It has resulted in the finding of many new variants and some interesting cases of thalassaemia, and in a study on the chemical structure of abnormal haemoglobins and DNA analysis of thalassaemia. We report here data on haemoglobin disorders in the Chinese, mainly the characterisation of the geographical distribution of haemoglobin variants, the analysis of globin genes of alpha, beta, gamma, or delta beta thalassaemia, and the progress in prenatal diagnosis of alpha and beta thalassaemia conducted in the authors' laboratory.