RT Journal Article SR Electronic T1 Immunogenetic studies in families with rheumatoid arthritis and autoimmune thyroid disease. JF Journal of Medical Genetics JO J Med Genet FD BMJ Publishing Group Ltd SP 451 OP 456 DO 10.1136/jmg.22.6.451 VO 22 IS 6 A1 Sanders, P A A1 Grennan, D M A1 Dyer, P A A1 de Lange, G G A1 Harris, R YR 1985 UL http://jmg.bmj.com/content/22/6/451.abstract AB HLA and Gm typing were carried out in 16 families. Seven families included 10 sib pairs with rheumatoid arthritis (RA) and autoimmune thyroid disease (ATD) respectively, and nine families included 16 sib pairs with RA and circulating thyroid autoantibodies respectively. Eight, 11, and seven sib pairs with either RA or clinical or immunological evidence of ATD shared none, one, and two HLA haplotypes respectively, and two, seven, and two informative sib pairs shared none, one, and two Gm haplotypes respectively. This random haplotype sharing of HLA and Gm haplotypes suggests that non-HLA, non-Gm linked genes are likely to be involved in any genetic predisposition common to RA and ATD.