RT Journal Article
SR Electronic
T1 Excess of cancer deaths in grandparents of patients with retinoblastoma.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 95
OP 101
DO 10.1136/jmg.17.2.95
VO 17
IS 2
A1 Bonaïti-Pellié, C
A1 Briard-Guillemot, M L
YR 1980
UL http://jmg.bmj.com/content/17/2/95.abstract
AB An excess of cancer deaths was found in grandparents of 308 children with retinoblastoma. This excess was found in all types of retinoblastoma, unilateral and bilateral, sporadic and familial. We postulated that the excess could be the result of a factor of susceptibility to cancer, different from the retinoblastoma gene, which would increase the mutation rate in retinal and germ cells as well as in other tissues.