RT Journal Article
SR Electronic
T1 An epidemiological and genetic study of facial clefting in France. II Segregation analysis.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 436
OP 440
DO 10.1136/jmg.21.6.436
VO 21
IS 6
A1 F Demenais
A1 C Bonaïti-Pellié
A1 M L Briard
A1 J Feingold
YR 1984
UL http://jmg.bmj.com/content/21/6/436.abstract
AB Familial transmission of cleft lip with or without cleft palate (CL(P] and isolated cleft palate (CP) was studied in two French samples of 458 CL(P) and 156 CP nuclear families, using the recently implemented unified model. In neither case could discrimination be achieved between polygenic inheritance and monogenic inheritance with a high proportion of sporadic cases. In this type of disorder with a complex genetic basis the information furnished by such an approach, which only considers the affected status, is discussed. Future investigations on the joint familial transmission of the disease and different marker systems may help to identify the genes involved in these developmental anomalies.