RT Journal Article
SR Electronic
T1 Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 129
OP 132
DO 10.1136/jmg.21.2.129
VO 21
IS 2
A1 M Nordenskjöld
A1 B Lambert
YR 1984
UL http://jmg.bmj.com/content/21/2/129.abstract
AB The male contraceptive agent gossypol was found to induce a dose related increase of DNA strand breaks in human fibroblasts in vitro at concentrations of 5 to 40 micrograms/ml. The effect was reduced in the presence of 2% fetal calf serum. A weak but reproducible increase in the SCE frequency was found in human lymphocytes treated for 1 hour in serum-free medium with 0.04 to 4 micrograms/ml of gossypol.