TY - JOUR T1 - Gossypol induces DNA strand breaks in human fibroblasts and sister chromatid exchanges in human lymphocytes in vitro. JF - Journal of Medical Genetics JO - J Med Genet SP - 129 LP - 132 DO - 10.1136/jmg.21.2.129 VL - 21 IS - 2 AU - M Nordenskjöld AU - B Lambert Y1 - 1984/04/01 UR - http://jmg.bmj.com/content/21/2/129.abstract N2 - The male contraceptive agent gossypol was found to induce a dose related increase of DNA strand breaks in human fibroblasts in vitro at concentrations of 5 to 40 micrograms/ml. The effect was reduced in the presence of 2% fetal calf serum. A weak but reproducible increase in the SCE frequency was found in human lymphocytes treated for 1 hour in serum-free medium with 0.04 to 4 micrograms/ml of gossypol. ER -