TY - JOUR T1 - Selective IgA deficiency with 18q+ and 18q-- karyotypic anomalies. JF - Journal of Medical Genetics JO - J Med Genet SP - 453 LP - 456 DO - 10.1136/jmg.17.6.453 VL - 17 IS - 6 AU - R M Lewkonia AU - C C Lin AU - R H Haslam Y1 - 1980/12/01 UR - http://jmg.bmj.com/content/17/6/453.abstract N2 - A case is described of selective immunoglobulin A deficiency in association with an 18q+ anomaly, apparently the result of a break at 18q23 and a de novo translocation. The presentation is compared with the phenotypic and immunological features in an IgA deficient 18q-- patient. The findings in these two patients suggest that gene(s) concerned with regulation of IgA synthesis are located on the distal long arm of chromosome 18 between 18q23 and qter. ER -