PT - JOURNAL ARTICLE AU - R M Lewkonia AU - C C Lin AU - R H Haslam TI - Selective IgA deficiency with 18q+ and 18q-- karyotypic anomalies. AID - 10.1136/jmg.17.6.453 DP - 1980 Dec 01 TA - Journal of Medical Genetics PG - 453--456 VI - 17 IP - 6 4099 - http://jmg.bmj.com/content/17/6/453.short 4100 - http://jmg.bmj.com/content/17/6/453.full SO - J Med Genet1980 Dec 01; 17 AB - A case is described of selective immunoglobulin A deficiency in association with an 18q+ anomaly, apparently the result of a break at 18q23 and a de novo translocation. The presentation is compared with the phenotypic and immunological features in an IgA deficient 18q-- patient. The findings in these two patients suggest that gene(s) concerned with regulation of IgA synthesis are located on the distal long arm of chromosome 18 between 18q23 and qter.