RT Journal Article
SR Electronic
T1 Monozygotic twins discordant for Wiedemann-Beckwith syndrome and the implications for genetic counselling.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 136
OP 138
DO 10.1136/jmg.17.2.136
VO 17
IS 2
A1 A C Berry
A1 E M Belton
A1 C Chantler
YR 1980
UL http://jmg.bmj.com/content/17/2/136.abstract
AB A pair of monozygous twins discordant for Wiedemann-Beckwith syndrome is described and published reports reviewed to establish the mode of inheritance. Single gene control seems unlikely and it is proposed that the condition arises from the interaction of "at risk" genes in the fetus and metabolic factors in the mother, which suggests multifactorial control.