%0 Journal Article %A A E Harding %A K J Zilkha %T 'Pseudo-dominant' inheritance in Friedreich's ataxia. %D 1981 %R 10.1136/jmg.18.4.285 %J Journal of Medical Genetics %P 285-287 %V 18 %N 4 %X A family is described in which Friedreich's ataxia occurred in two generations. It is proposed that this resulted from a homozygote-heterozygote mating. The heterozygote frequency for the Friedreich's ataxia gene is in the order of 1 in 110, so the likelihood of the disease developing in an individual child of a patient is 1 in 220. This risk is probably higher than that often assumed when counselling patients with this disorder. %U https://jmg.bmj.com/content/jmedgenet/18/4/285.full.pdf