PT  - JOURNAL ARTICLE
AU  - Kingston, H M
AU  - Thomas, N S
AU  - Pearson, P L
AU  - Sarfarazi, M
AU  - Harper, P S
TI  - Genetic linkage between Becker muscular dystrophy and a polymorphic DNA sequence on the short arm of the X chromosome.
AID  - 10.1136/jmg.20.4.255
DP  - 1983 Aug 01
TA  - Journal of Medical Genetics
PG  - 255--258
VI  - 20
IP  - 4
4099  - http://jmg.bmj.com/content/20/4/255.short
4100  - http://jmg.bmj.com/content/20/4/255.full
SO  - J Med Genet1983 Aug 01; 20
AB  - A study of DNA restriction fragment polymorphisms and Becker muscular dystrophy has shown eight families informative for the cloned sequence L1.28, which is located on the short arm of the X chromosome between Xp110 and Xp113. Analysis of these families reveals linkage between the two loci, with the maximum likelihood estimate of the genetic distance being 16 centiMorgans (95% confidence limits between 7 and 32 centiMorgans). Since a study of DNA polymorphisms in Duchenne muscular dystrophy has shown a comparable linkage distance with L1.28, our results suggest that the locus for Becker muscular dystrophy, like that for Duchenne dystrophy, is on the short arm of the X chromosome, and further that these two loci may be closely linked or possibly allelic.