PT  - JOURNAL ARTICLE
AU  - Morten, J
AU  - Harnden, D G
AU  - Bundey, S
TI  - Family studies on the chromosomal location of the retinoblastoma gene (Rb-1).
AID  - 10.1136/jmg.19.2.120
DP  - 1982 Apr 01
TA  - Journal of Medical Genetics
PG  - 120--124
VI  - 19
IP  - 2
4099  - http://jmg.bmj.com/content/19/2/120.short
4100  - http://jmg.bmj.com/content/19/2/120.full
SO  - J Med Genet1982 Apr 01; 19
AB  - The segregation of chromosomes 13 distinguishable by Q band fluorescent polymorphisms has been studied in three families with retinoblastoma. The recombination fraction for two of these families and four families previously reported did not differ significantly from 50%. Since a high recombination fraction has been predicted from chiasma frequency between the centromere of chromosome 13 and 13q14 these results neither confirm nor refute the location of the autosomal dominant gene predisposing to retinoblastoma in 13q14. The use of fluorescent markers is not suitable for early recognition of gene carriers in families with retinoblastoma.