RT Journal Article
SR Electronic
T1 An epidemiological and genetic study of facial clefting in France. I. Epidemiology and frequency in relatives.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 8
OP 15
DO 10.1136/jmg.19.1.8
VO 19
IS 1
A1 Bonaiti, C
A1 Briard, M L
A1 Feingold, J
A1 Pavy, B
A1 Psaume, J
A1 Migne-Tufferaud, G
A1 Kaplan, J
YR 1982
UL http://jmg.bmj.com/content/19/1/8.abstract
AB The frequencies of cleft lip with or without cleft palate (CL(P)) and isolated cleft palate (CP) have been estimated in France to be 0.082% and 0.035%, respectively, after exclusion of malformation syndromes. A genetic and epidemiological study has been carried out on 468 patients with CL(P) and 163 with CP. The results are given in detail and some specific points are discussed: the apparently low incidence in France, the relationship between sex ratio and abortion rates, the maternal effects, and the possibility of an association between CL(P) and CP.